额颞叶肿瘤患者手术前后大脑网络特性研究

脑肿瘤患者大脑的损伤及手术对大脑认知的影响是目前临床最为关注的问题。基于静息态fMRI脑功能分析技术及小世界网络分析方法,研究9例脑额颞叶肿瘤患者的大脑肿瘤对大脑默认模式网络和感觉运动网络的影响,以及肿瘤切除对大脑功能网络特性的改变。首先基于ICA方法,研究肿瘤及手术切除对患者大脑默认网络和感觉运动网络的影响;接着构建肿瘤患者术前术后和正常对照组的小世界网络,对网络的拓扑特性和网络参数进行分析;然后运用介数中心度,求出各组的脑功能网络核心节点,并比较分析患者和正常人、患者术前术后核心节点的变化;最后比较分析患者术前、术后默认模式网络和感觉运动网络中脑区的具体变化。研究结果发现,默认模式网络和感觉运动网络神经活动活跃程度降低,证明肿瘤病灶对大脑内源性网络的两个模块造成了明显的损害;患者术后的小世界属性(σ=γ/λ)显著降低(术前:3.591±0.302,术后:3.263±0.174),簇系数显著降低(术前:0.482±0.007,术后:0.454±0.011),并且脑肿瘤使核心节点向肿瘤对侧偏移。默认网络中手术后肿瘤的切除使得右侧脑区(原肿瘤侧)活动变得强烈,右脑介数中心度值明显上升(术前:0.012 5±0.000 5,术后:0.018 4±0.001 0);左脑活动有所缓和,左侧介数中心度值显著下降(术前:0.018 0±0.001 1,术后:0.012 2±0.000 6)。术后部分被抑制的节点又重新激活。通过对病人的默认模式网络和感觉运动网络的研究,发现肿瘤对患者大脑功能网络有一定的破坏,术后会有所改善。研究结果表明,由于大脑高级神经皮层的重组性和代偿机制,脑肿瘤患者术后可能出现功能恢复。

Study on the Brain Network Characteristics before and after the Operation of Frontotemporal Tumor Patients

Brain injury and surgery in brain tumor patients are the most concerned problems in clinical treatments. Based on resting state functional magnetic resonance imaging (fMRI) technology and small world network analysis method, this paper is to study the effect of tumor on the brain's default mode network and sensory motor network in 9 patients with temporal frontal lobe tumor. And the changes of brain function network characteristics were studied by tumor resection. First, the effect of the tumor and resection on the brain's default network and sensory motor network was studied based on the ICA method. Then, the small world network of the patients and normal control group were constructed. The network topology and network parameters were analyzed. We used the betweenness centrality to find out groups of brain functional network core node, and a comparative analysis of changes in patients and normal people at the core node, and preoperative and postoperative core nodes change. Finally, a comparative analysis was conducted on the patients before surgery and after the default mode networks and sensory motor network midbrain region specific changes. The results showed that the nerve activity in default mode network and sensory sports network became lower, suggesting significant damage caused by the tumor in the brain of two modules endogenous network. The small-world attributes(σ=γ/λ)of the patients were significantly reduced (preoperative: 3.591±0.302, postoperative: 3.263±0.174), the cluster coefficients were significantly lower (preoperative: 0.482±0.007, postoperative: 0.454±0.011), and the core nodes shifted to the contralateral side of the tumor. In default network, the resection of the tumor after the operation makes the right brain area activity becomes stronger (preoperative: 0.0125±0.0005, postoperative: 0.0184±0.0010). The activity of the left side of the brain is alleviated. (preoperative: 0.0180±0.0011, postoperative: 0.0122±0.0006). Through the study of the patient's default mode network and sensory motor network, the temporal frontal lobe tumor has a certain effect on the patient's cognitive ability and motor ability, and these abilities could be recovered after surgery.