脑微出血危险因素及其与认知功能的相关性研究

目的 探讨脑微出血（cerebral microbleeds，CMBs）患者认知功能损害的临床特征及其相关因素。 

Risk Factors of Cerebral Microbleeds and Its Correlation with Cognitive Impairment

Objective To examine the clinical characteristics and correlative factors of cognitive dysfunction
in patients with cerebral microbleeds (CMBs).
Methods A total of 30 patients with SVD and 30 age, sex and education-matched control subjects
were recruited consecutively from department of neurology, Beijing Tongren hospital. The cognitive
function of all participants were evaluated by neuropsychological tests, including mini-mental
state examination (MMSE), Montreal cognitive assessment (MoCA). The severity of white matter
lesions was evaluated by the Fazekas scale, and the severity of CMBs by the microbleed anatomical
rating scale (MARS). The correlation between the severity of CMBs and white matter lesions/
cognitive function were analyzed.
Results We found that CMBs was related to global cognitive function deficits. The severity of CMBs
was positively related to the severity of white matter lesions (r =0.431, P =0.03). The severity of CMBs
was negatively related to the score of MoCA (r =-0.52, P =0.02).
Conclusion CMBs was closely related to cognitive impairment. The severity of CMBs was
negatively related to the score of MoCA, and the severity of CMBs was positively related to the
severity of white matter lesions.