Effect of ipratropium bromide on respiratory mechanics in infants with acute bronchiolitis |
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| Authors: | J Seidenberg I B Masters I Hudson A Olinsky P D Phelan |
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| Affiliation: | Professional Department of Thoracic Medicine, Royal Children's Hospital, Parkville, Victoria, Australia. |
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| Abstract: | The effect of nebulized ipratropium bromide in 14 infants (mean age: 20 weeks, range: 4-41) with acute respiratory syncytial virus bronchiolitis was examined. A modified rapid chest compression technique was used to obtain partial expiratory flow-volume curves and maximum flow at functional residual capacity. Passive respiratory mechanics were assessed by brief occlusion at end inspiration. Thoracic gas volume was measured in a body plethysmograph. No significant difference was found in forced and passive respiratory mechanics pre- and post-ipratropium bromide. No subgroups could be identified. These results do not support the use of ipratropium bromide in acute viral bronchiolitis. |
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