| 八仙草化学成分研究 |
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| 引用本文： | 李建,李彬,陈立,刘士军,董俊兴.八仙草化学成分研究[J].军事医学科学院院刊,2010,34(3):269-271. |
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| 作者姓名： | 李建 李彬 陈立 刘士军 董俊兴 |
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| 作者单位： | 军事医学科学院放射与辐射医学研究所,北京,100850 |
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| 摘 要： | 目的对中草药八仙草（Galium aparineL.）全草的60%乙醇提取物进行化学成分研究。方法采用硅胶柱色谱、Sephadex LH-20凝胶柱色谱及制备薄层等方法进行分离纯化,通过波谱解析和理化鉴别进行结构鉴定。结果分离鉴定了11个化合物,分别为对羟基苯甲酸（1）,香草酸（2）,原儿茶酸（3）,胞嘧啶（4）,胞嘧啶核苷（5）,尿嘧啶（6）,尿嘧啶核苷（7）,腺嘌呤核苷（8）,1,3-二羟基蒽醌（9）,1,3,6-三羟基-2-甲基蒽醌-3-O-新橙皮糖苷（10）,1,4-二羟基-3-异戊烯基-2-萘酸甲酯双葡萄糖苷（11）。结论化合物1-11均为首次从该植物中分离得到。
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| 关 键 词： | 中草药 八仙草 植物提取物 色谱法 凝胶 蒽醌 萘酸酯 化学成分 |
Chemical constituents of Galium aparine |
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| LI Jian,LI Bing,CHEN Li,LIU Shi-jun,DONG Jun-xing.Chemical constituents of Galium aparine[J].Bulletin of the Academy of Military Medical Sciences,2010,34(3):269-271. |
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| Authors: | LI Jian LI Bing CHEN Li LIU Shi-jun DONG Jun-xing |
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| Institution: | (Institute of Radiation Medicine,Academy of Military Medical Sciences,Beijing 100850,China) |
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| Abstract: | Objective To investigate the chemical constituents of 60% alcohol extract of Galium aparine L.Methods The compounds were isolated by column chromatography over silica gel and Sephadex LH-20 coupled with preparative silica gel TLC.Structures of the compounds were elucidated on the basis of physicochemical properties and spectral data.Results Eleven compounds were isolated and identified as 4-hydroxybenzoic acid（1）,vanillic acid（2）,protocatechuic acid（3）,cytosine（4）,cytidine（5）,uracil（6）,uridine（7）,adenosine（8）,xanthopurpurin（9）,2-methyl-1,3,6-trihydroxy-9,10-anthraquinone-3-O-α-rhamnosyl（1→2）-β-D-glucoside（10）,2-carbomethoxy-3-prenyl-1,4-naphthohydroquinone-di-O-β-D-glucoside（11）,respectively.Conclusion Compounds 1-11 are isolated from this plant for the first time. |
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| Keywords: | drugs Chinese herbal Galium aparine plant extracts chromatography gel anthraquinone naphthohydroquinone chemical constituents |
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