A biochemical approach to periodontal regeneration: Tetracycline treatment of dentin promotes fibroblast adhesion and growth |
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| Authors: | Victor P.,Terranova ,Louis C.,Franzetti ,Susanne,Hic ,Roberta M.,Diflorio ,Raymond M.,Lyall ,Ulf M. E.,Wikesjö ,Pamela J.,Baker ,Lars A.,Christersson Robert J.,Genco |
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| Affiliation: | Laboratory of Tumor Biology and Connective Tissue Research, Biotechnology Research Center, Rockville, Maryland, and Department of Oral Biology, and the Periodontal Disease Clinical Research Center, State University of New York at Buffalo, USA |
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| Abstract: | One objective of periodontal therapy after resolution of the infectious process is to facilitate a new connective tissue attachment to the root dentin surface. Here we report that a selective advantage for attachment and growth can be conferred on human gingival fibroblasts by biochemical manipulation of the dentin surface. Tetracycline HCL treatment of the dentin surface increases binding of fibronectin. The adsorbed fibronectin stimulates fibroblast attachment and growth, while suppressing epithelial cell attachment and growth. This biochemical manipulation may provide a useful approach for the treatment of periodontally involved teeth. |
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