Primidone and essential tremor |
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Authors: | S. Seyfert A. Honé G. Holl |
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Affiliation: | (1) Neurologische Klinik, Freie Universität Berlin, D-100 Berlin 45;(2) Abteilung für Klinische Neurophysiologie, Klinikum Steglitz, Freie Universität Berlin, D-1000 Berlin 45 |
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Abstract: | Summary To clarify whether primidone itself, and not only its metabolite phenobarbitone, suppresses essential tremor, the effect of a high single dose of primidone was tested. Of 11 patients, 8 showed a reduction of their tremor by 54%–69% for up to 28h. The serum concentration of primidone was as expected, whereas those of the metabolites phenyl-ethylmalonamide and phenobarbitone were very low. The tremor suppression can thus be considered to be an effect of primidone. Three of the 11 patients did not show a reduction of tremor. |
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Keywords: | Primidone Essential tremor |
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