| 脑星形细胞肿瘤中FAK、Pyk2表达及其与血管生成的关系 |
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| 作者单位： | Zhiqiang Li，Xianhou Yuan，Zhimin Wu，Zhiwang Guo，Pucha Jiang，Zhihua WenDepartment of Neurosurgery，Zhongnan Hospital of Wuhan University，Wuhan 430071，China |
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| 基金项目： | 湖北省卫生厅科研项目，武汉大学科学研究基金 |
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| 摘 要： | Objective: To study the expressions of FAK and Pyk2 in human astrocytic tumors and their relationship with an-giogenesis. Methods: The S-P immunohistochemical method was used to measure the expressions of FAK, Pyk2 and VEGF proteins in 58 human brain astrocytic tumors, and microvessel density (MVD) was detected by CD31 staining. Results: In astrocytic tumors with I, II, III and IV grades, the positive rates of FAK were 20.00%, 26.67%, 44.44% and 50.00%, respec-tively, those of Pyk2 were 40.00%, 60.00%, 77.78% and 85.00%, respectively. FAK and Pyk2 expressions, especially Pyk2, correlated positively with VEGF expression and MVD. Conclusion: FAK and Pyk2 plays the important role in astrocytic tumor angiogenesis through regulation to VEGF.
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| 关 键 词： | 星细胞瘤 FAK Pyk2 血管发生 |
Expressions of FAK and Pyk2 in human astrocytic tumors and their relationship with angiogenesis |
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| Authors: | Zhiqiang Li Xianhou Yuan Zhimin Wu Zhiwang Guo Pucha Jiang Zhihua Wen |
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| Institution: | Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China |
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| Abstract: | Objective: To study the expressions of FAK and Pyk2 in human astrocytic tumors and their relationship with angiogenesis. Methods: The S-P immunohistochemical method was used to measure the expressions of FAK, Pyk2 and VEGF proteins in 58 human brain astrocytic tumors, and microvessel density (MVD) was detected by CD31 staining. Results: In astrocytic tumors with Ⅰ,Ⅱ,Ⅲ and Ⅳ grades, the positive rates of FAK were 20.00%, 26.67%, 44.44% and 50.00%, respeclively, those of Pyk2 were 40.00%, 60.00%, 77.76% and 85.00%, respectively. FAK and Pyk2 expressions, especially Pyk2, correlated positively with VEGF expression and MVD. Conclusion: FAK and Pyk2 plays the important role in astrocytic tumor angiogenesis through regulation to VEGF. |
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| Keywords: | astrocytic tumor FAK Pyk2 angiogenesis |
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