抗菌药物诱导内毒素的产生及抗内毒素药物的研究进展

内毒素是革兰阴性菌的主要致病成分,抗菌药物在杀/抑菌的同时会诱导内毒素的产生,增加了疾病的治疗难度。体外实验、动物实验证实,抗菌药物诱导内毒素的产生与多种因素有关,提示在临床选用抗菌药物时应对药敏实验结果及其诱导内毒素释放的特性进行综合考虑。抗内毒素药物的研究近年取得了一些成效,其中中药制剂也显示了很好的抗内毒素作用,相信这类药物会有广阔的发展前景。

Study on the anti-endotoxin agents and the induction of endotoxins by antibacterials

Endotoxin has been recognized as a major player in the pathogenesis of Gram negative bacteria,and more,the induction of endotoxins had resulted in complexity antibacterial therapy.In vitro and animal studies revealed that the endotoxins induced by antibacterial agents were closely correlated with various factors.Therefore,in the course of evaluating results of susceptibillity test,the consequence of endotoxins released should also not be ignored.Recently,studies of anti-endotoxin agents had notably progressed,for instance,in the field of Traditional Chinese Medicine preparations,had demonstrated the potential of anti-endotoxin activities and the promising future could be expected.