中药联合体外受精-胚胎移植治疗多囊卵巢综合征临床研究

目的 评价补肾调冲中药联合体外受精－胚胎移植(IVF-ET)治疗多囊卵巢综合征（PCOS）患者的有效性。 方法 将64例行IVF-ET的PCOS患者按随机数字表法分为观察组（36例）和对照组（28例），观察组加服补肾调冲中药二至天癸颗粒。 结果 注射绒毛膜促性腺激素（HCG）日子宫内膜分型，观察组A级分型所占的比例为75.0%（27/36），对照组为42.9%（12/28），两组比较差异有统计学意义（P<0.01）；观察组的优质卵率、受精率、优质胚胎率、临床妊娠率及卵巢过度刺激综合征（OHSS）发生率分别为（76.8±8.2）%、（73.5±8.9）%、（89.4±14.4）%、36.11%（13/36）及5.56%（2/36）；而对照组分别为（64.4±8.7）%、（68.2±10.0）%、（79.5±15.2）%、21.43%（6/28）及10.71%（3/28），两组比较差异均有统计学意义（P<0.05）；促性腺激素（Gn）用量，观察组为(33.8±12.5)支，对照组为（47.6±18.2）支（每支75 IU），两组比较差异有统计学意义（P<0.01）；取卵数目两组比较差异无统计学意义。 结论 在IVF-ET过程中联合应用补肾调冲中药可减少Gn用量，提高临床妊娠率。

Combined Therapy of Chinese Medicine with in vitro Fertilization and Embryo Transplantation for Treatment of Polycystic Ovarian Syndrome

Objective To evaluate the validity of Chinese drugs for reinforcing Shen and regulating Chong channel （RSRCC） on patients with polycystic ovarian syndrome （PCOS） undergoing in vitro fertilization and embryo transplantation （IVF-ET）. Methods Sixty-four patients with PCOS undergoing IVF-ET were randomly assigned to two groups, the treated group （36 cases） and the control group （28 cases）, to the former, Chinese recipe for RSRCC was given additionally. Results On the human chorionic gonadotrophin （HCG） injecting day, the percentage of three-line sign of endometrium （type A） in the treated group was 75.0% （27/36） , which was higher than that in the control group （42.9% , 12/28） , showing significant difference between the two groups （P 〈 0.01 ）. The rates of mature oocytes, fertilization, high-qualified embryo rate, clinical pregnancy rate and incidence rate of ovary hyper-stimulating syndrome （OHSS） in the treated group were （76.8 ± 8.2） %, （73.5 ± 8.9） % , （89.4±14.4）%, 36.11% （13/36） and 5.56% （2/36）, respectively; whereas those in the control group （64.4 ±8.7）%, （68.2 ±10.0）%, （79.5 ±15.2）%, 21.43% （6/28）and 10.71% （3/28）; the dosage of gonadotrophin administered in the treated group was 33.8 ± 12.5 ampoules, and in the control group 47.6 ± 18.2 amp oules, statistical significance was shown between groups in comparing all the above-mentioned parameters （P 〈0.05, P 〈 0.01 ）. However, the number of oocytes obtained in the two groups was insignificantly different （P 〉 0.05）. Conclusion Combined use of Chinese drugs for RSRCC in IVF-ET can reduce the dosage of gonado-trophin administered and raise the clinical pregnant rate.