兔VX2鼻咽移植癌的PET-CT与病理结果对照研究

目的:观察VX2兔鼻咽癌生长特点,并与所获病理和MRI结果比较,探讨18F-FDGPET-CT在鼻咽肿物检测中的作用。方法:建立VX2兔鼻咽癌模型后,完成18F-FDGPET-CT和MRI扫描并解剖;在肉眼所见肿瘤周围不同的距离取标本并完整取出斜坡作病理诊断;测量鼻咽肿物最大标准摄取值(SUV),在PET-CT和MRI图像上勾画鼻咽肿物体积。结果:VX2兔鼻咽癌可向周围组织呈广泛浸润性生长;30只兔中经病理确诊有9只兔斜坡受癌细胞侵犯,PET-CT发现6例(66.7%),MRI发现5例(55.6%),CT发现1例(11.1%);兔VX2鼻咽癌的最大SUV值与鼻咽肿物的体积呈负相关,r=-0.426,P=0.03;30只兔在18F-FDGPET-CT图像上所勾画的鼻咽肿物体积较在MRI图像上勾画体积小,差异无统计学意义,P=0.17。结论:18F-FDGPET-CT能对鼻咽癌病灶范围的确定、放疗靶区的准确勾画提供有用的信息。

Comparative study on 18F-deoxyglucose positron emission tomography computed tomography and pathology diagnoses in rabbit VX2 nasopharyngeal carcinoma

OBJECTIVE:To observe the charactertics of the growth of rabbit VX2 nasopharyngeal carcinoma(NPC)primary lesion and explored the role of 18F-deoxyglucose positron emission tomography computed tomography(18F-FDG PET-CT)on NPC.Based on the pathology results compared with magnetic resonance imaging(MRI).METHODS:After the establishment of a rabbit VX2 NPC model,18F-FDG PET-CT,MRI and anatomy were performed.The pathology diagnoses of specimen from different distances of tumor edge through naked eyes and the pathology diagnoses of clivus were obtained.Meanwhile SUVmax of NPC and delineated tumor volume on PET-CT and MRI images were measured.RESULTS:VX2 rabbit NPC primary lesion invasively grew to invade the surrounding tissues and organs.The clivus of 9 rabbits were invaded by cancer cells histologically proven in total 30 VX2 NPC rabbits,and PET-CT found 6(66.7%),MRI found 5(55.6%)and CT found 1(11.1%).NPC SUVmax was negatively correlated with NPC volume(r=-0.426,P=0.03).The volume based on 18F-FDG PET-CT images was smaller than that on MRI image,but there was no significantly difference between them(P=0.17).CONCLUSION:Based on pathology data,18F-FDG PET-CT is proved as an important tool to find of tumor and help to definite tumor targets.