| 济南地区淋球菌耐药性检测及质粒谱型分析 |
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| 引用本文： | 侯存军,刘庆东,吴学忠,李娜,李中伟,侯建玲,赵毅,张健.济南地区淋球菌耐药性检测及质粒谱型分析[J].中国皮肤性病学杂志,2008,22(1):34-36. |
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| 作者姓名： | 侯存军 刘庆东 吴学忠 李娜 李中伟 侯建玲 赵毅 张健 |
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| 作者单位： | 山东省皮肤病性病防治研究所,山东,济南,250022 |
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| 摘 要： | 目的了解济南地区淋球菌对抗生素的耐药性和质粒图谱。方法用琼脂稀释法测定4种抗生素对148株淋球菌的最小抑菌浓度(MIC)及其中70株淋球菌的质粒图谱。结果检出PPNG占28.38%,TRNG占18.92%,环丙沙星耐药达98.99%,头孢曲松、大观霉素未发现耐药菌株。质粒谱型主要有4.2kb+5.4kb(38.58%),4.2kb+7.4kb(20.00%),4.2kb+5.4kb+39.5kb(15.71%)。结论济南地区淋球菌对抗生素耐药性维持在较高水平,头孢曲松、大观霉素是治疗首选;质粒图谱显示出地域特殊性。
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| 关 键 词： | 淋病奈瑟菌 最低抑菌浓度 耐药性 质粒 |
| 文章编号： | 1001-7089（2008）01-0034-02 |
| 收稿时间： | 2007-02-09 |
| 修稿时间： | 2007-04-17 |
Study on The Antibiotuc Resistance and Plasmid Profiles of Neisseria Gonorrhoeae in Jinan |
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| HOU Cun-jun, LIU Qing-dong,WU Xue-zhong,et al.Study on The Antibiotuc Resistance and Plasmid Profiles of Neisseria Gonorrhoeae in Jinan[J].The Chinese Journal of Dermatovenereology,2008,22(1):34-36. |
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| Authors: | HOU Cun-jun LIU Qing-dong WU Xue-zhong |
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| Abstract: | Objective To survey the antibiotic resistance and plasmid profiles of Neisseria gonorrhoeaes in Jinan.Methods Four kinds of antibiotics were used to detect the minimum inhibitory concentrations(MIC) of one hundred forty-eight Neisseria gonorrhoeaes,and the plasmid profiles of seventy Neisseria gonorrhoeaes.Results The rates of PPNG and TRNG were 28.38% and 18.92%.the resistance rate for ciprofloxacin was 99.32%.there was no resistance to ceftriaxone sodium and spectinomycin.The main plasmid profiles were 4.2kb 5.4kb(38.58%),4.2kb 7.4kb(20.00%)and 4.2kb 5.4kb 39.5kb(15.71%).Conclusion The antibiotic resistance of Neisseria gonorrhoeaes in Jinan was at a high level.Ceftriaxone sodium and spectinomycin were still the first choice.The plasmid profiles had its specificity. |
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| Keywords: | Neisseria gonorrhoeae Minimal inhibitory concentration(MIC) Resistance Plasmid |
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