某河流沿岸原发性肝癌危险因素的病例对照研究

目的了解该河沿岸地区原发性肝癌(PHC)的主要危险因素,为降低该地区PHC发病率提供理论依据.方法采用直接询问法,以沿河地区65例PHC患者为病例组,以远离河岸的与病例组年龄相差在5岁以内、不同姓氏、生活习惯、种植情况和生活水平等方面基本相近的居民为对照组.结果经单因素分析得出可能的危险因素有:家庭年人均收入、个人肝病史、PHC家族史、蔬菜摄入量情况、常吃盐渍食品、饮用渗水井(土井)、饮水类型、饮酒年数、负性生活事件和性格类型,经Logistic回归分析得出只有饮用渗水井(土井)、个人肝病史、饮酒和PHC家族史为有意义的预防措施. 结论该河沿岸居民的PHC的主要危险因素有:个人肝病史、饮酒和PHC家族史,距离该河越近的饮用水水质越差,这可能是离河岸近的浅层地下水易受污染所致.预防和控制奎濉河沿岸PHC最根本、最有效的措施是治理污染和打深水井.

A case-control study for detecting risk factors of primary hepatocellular carcinoma among residents along one river

Objective To explore major risk factor and etiological patterns of primary hepatocellular carcinoma (PHC) among the residents along one river so as to provide a scientific basis for effective prevention of PHC. Methods A case-control study was conducted in residents along one river.The study population include 65 diagnosed patients with PHC, and 65 controls as a representative sample of residents in the same area, which frequency-matched to the expected distributions of case by gender and age(5-years groups). The data were processed with software of EpiInfo 6.04 and SPSS 10.0. Results Univariable logistic regression analysis showed that possible risk factors were average income per capita, individual history of liver disease,family history of PHC,wading pool water,vegetable intake,pickled food intake,low well, type of drinking water,liquor drinking,negative life-events and character. Analyzed by multiple logistic regression, factors that finally entered the model were drinking water,history of liver disease, liquor drinking and family history of PHC. Conclusion The above results suggest that major risk factors are drinking water,history of liver disease,liquor drinking and family history of PHC. Thus, according to the results of this study,we considere that it will be an important preventive strategy and measure to meliorate drinking water for eliminating PHC ultimately.