| 真菌来源白细胞介素6受体拮抗剂2520A的研究 |
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| 引用本文： | 朱凤昌,姜蓉,张洋,吴剑波,李元. 真菌来源白细胞介素6受体拮抗剂2520A的研究[J]. 药学学报, 2006, 41(7): 662-665 |
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| 作者姓名： | 朱凤昌 姜蓉 张洋 吴剑波 李元 |
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| 作者单位： | 中国医学科学院、中国协和医科大学,医药生物技术研究所,北京,100050 |
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| 摘 要： | 目的从真菌Torulomyces ovatus的代谢产物中分离白细胞介素6受体(IL-6R)拮抗剂。方法利用多种柱色谱进行分离纯化对IL-6R具拮抗活性的物质，根据理化性质、光谱数据确定其结构。结果从真菌Torulomyces ovatus的代谢产物中得到对IL-6R有拮抗活性的化合物2520A。结论2520A化合物为已知铁螯合物ferrichrome，首次报道该化合物具IL-6R拮抗活性，并确定其结构含有铁原子。
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| 关 键 词： | 白细胞介素6受体拮抗剂 真菌Torulomyces ovatus 2520A |
| 文章编号： | 0513-4870（2006）07-0662-04 |
| 收稿时间： | 2005-11-25 |
| 修稿时间： | 2005-11-25 |
A IL-6R antagonist 2520A produced by a Fungal species |
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| ZHU Feng-chang,JIANG Rong,ZHANG Yang,WU Jian-bo,LI Yuan. A IL-6R antagonist 2520A produced by a Fungal species[J]. Acta pharmaceutica Sinica, 2006, 41(7): 662-665 |
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| Authors: | ZHU Feng-chang JIANG Rong ZHANG Yang WU Jian-bo LI Yuan |
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| Affiliation: | Institute of Medical Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beifing 100050, China |
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| Abstract: | Aim To isolate IL-6R antagonists from the cultured broth of the strain Torulomyces ovatus.Methods Various column chromatographyes were used to separate and purify the compounds with IL-6R antagonist activity.The spectral data and physic-chemical properties were measured for structure identification.Results One compound namely 2520 was isolated from the cultured broth of Torulomyces ovatus.Conclusion 2520A is a known compound(ferrichrome).It is first reported about its antagonistic activity of IL-6R and identification of iron atom in its structure. |
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| Keywords: | 2520A |
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