依那普利和洛沙坦对自发性高血压大鼠血管重塑的影响

目的：观察自发性高血压大鼠胸主动脉结构的改变，以及依那普利和洛沙坦的保护作用。方法：雄性自发性高血压大鼠自１０周龄始，给予依那普利，洛沙坦，或二者半剂量合用６周，并以年龄、性别、数量相同的未治疗自发性高血压大鼠和正常组作对照。测量收缩压和血管壁胶原含量，计算机图象分析血管外膜面积、中膜面积、管腔面积和管壁厚度。结果：自发性高血压大鼠未治疗组的收缩压、血管壁胶原含量、外膜面积、中膜面积和管壁厚度均显

THE EFFECTS OF ENALAPRIL AND LOSARTAN ON VASCULAR REMODELING IN SPONTANEOUSLY HYPERTENSIVE RATS

Objective: To investigate the structural changes of aorta in spontaneously hypertensive rats (SHR), and the protective role of enalapril and losartan. Methods: We administed angiotensin converting enzyme (ACE) inhibitor (enalapril 20mg.kg-1.d-1), AngII receptor type 1 (AT1) antagonist (losartan 25mg.kg-1.d-1), or their combination at half doses (enalapril 10mg.kg-1.d-1, losartan 12.5mg.kg-1.d-1) to SHR from 10 to 16 weeks of age. Male, age-matched untreated SHR (SHRc) and Wistar-Kyoto (WKY) rats served as controls. Systolic blood pressure (SBP) and vascular collagen contents were determined. Adventitia, media and lumen cross-sectional area, wall thickness of the aorta were assessed with computed video processing. Results: Compared with WKY rats, the SBP, vascular collagen contents, adventitia and media cross-sectional area and wall thickness were significantly increased in SHRc ( P <0.001), which were significantly reduced in treated SHR than in SHRc. There were no different in lumen cross-sectional area between each group ( P >0.05). Conclusions: In early stage of SHR, the major structural changes of aorta are the alternation of the vessel wall. Enalapril and losartan can effectively decreased blood pressure, improve vascular remodeling.