Oxatomide protectsTrichinella spiralis infected mice from lethal anaphylaxis |
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Authors: | Fred De Clerck Ludo Van Gorp Oscar Vanparijs Marcel Borger Frans Awouters |
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Affiliation: | (1) Research Laboratories, Janssen Pharmaceutica, B-2340 Beerse, Belgium |
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Abstract: | Infection withTrichinella spiralis in mice was accompanied by allergic sensitization as evidenced by anaphylactic death after intravenous injection of the antigen. Pre-treatment of the animals with oxatomide, a new orally active antiallergic drug, resulted in significant protection of the animals; the lowest effective dose of the compound was 1.25 mg/kg orally. In contrast to cyproheptadine, oxatomide offered little protection against serotonin toxicity in mice.The present data suggest that, in this model of systemic hypersensitivity, the anti-anaphylactic effect of oxatomide can be attributed mainly to inhibition of release of allergic mediators. |
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