| 皮肤低温损伤机制中海藻糖的抗氧自由基作用 |
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| 引用本文： | 贾晓明,蔡宏.皮肤低温损伤机制中海藻糖的抗氧自由基作用[J].军医进修学院学报,2005,26(6):435-436. |
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| 作者姓名： | 贾晓明 蔡宏 |
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| 作者单位： | 解放军总医院第304临床部,全军烧伤研究所,北京,100037 |
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| 基金项目： | 国家自然科学基金项目（30070298） |
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| 摘 要： | 目的：观察海藻糖在低温储存皮肤组织中的抗氧自由基损伤作用。方法：取新鲜皮肤标本做正常对照组，另行海藻糖和二甲基亚砜处理后液氮低温储存，复温后测定皮肤组织匀浆液中超氧化物歧化酶（SOD）活力，过氧化脂质（LPO）代谢产物丙二醛（MDA）含量。结果：经海藻糖处理后，低温储存的皮肤组织中SOD活力升高，其MDA含量下降。结论：海藻糖是一种有效的稳定剂，在皮肤低温损伤中具有抗氧自由基损伤作用。
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| 关 键 词： | 海藻糖 氧 自由基 低温 皮肤 |
| 文章编号： | 1005-1139（2005）06-0435-02 |
| 收稿时间： | 2005-01-04 |
| 修稿时间： | 2005-02-06 |
Trehalose's protective effects of cryopreserved skin to resist the damage of oxygeon free radical |
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| JIA Xiao-ming,CAI Hong.Trehalose''''s protective effects of cryopreserved skin to resist the damage of oxygeon free radical[J].Academic Journal of Pla Postgraduate Medical School,2005,26(6):435-436. |
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| Authors: | JIA Xiao-ming CAI Hong |
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| Institution: | Department of Burns and Plastic Surgery, Burns Institute, PLA General Hospital, Beijing 100037, China |
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| Abstract: | Objective:To investigate the protective effects of trehalse during cryoinjury.Methods:Evaluate the level of superoxide dismutaes(SOD) and the amount of malonyldialdehyde(MDA) from the cryopreserved skin.Results:Comparing to the normal human skin, trehalose could enhance the vitality of SOD and decrease the production of MDA when the skin was frozen.(Conclusion:)It showed that trehalose may promote the ability on elimination of oxygen free radical and decrease the attack of the oxygeon free radical during cryoinjury.trehalose;oxygeon;free radical;hypothermia;skin |
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| Keywords: | trehalose oxygeon free radical hypothermia skin |
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