大剂量激素对脑创伤家兔脑微循环及血液流变性的影响

为探讨大剂量激素对脑创伤后脑微循环及血液流变性的影响，将２４只家兔随机等分为３组：标准对照组、损伤对照组和地塞米松治疗组。分别在伤前０．５ｈ、伤后０．５ｈ、１ｈ、２ｈ、３ｈ测量软脑膜微动脉管径和血流速度的变化及伤后３ｈ血液流变学指标。结果表明：大剂量激素在伤后０．５ｈ就能明显地扩张损伤处软脑膜的微动脉并使血流速度明显加快。伤后３ｈ能明显降低血沉、全血粘度、红细胞压积及纤维蛋白原含量，并明显增强红细胞的变形能力，降低其聚集性。这些结果表明大剂量激素能明显改善脑创伤后家兔的脑微循环及血液流变性

Effects of High-Dose Dexamethasone on Cerebral Microcirculation and Hemorheology in Rabbits with Cerebral Trauma

To understand the effects of high-dose dexamethasone on pia mater microcirculation and hemorheology,24 rabbits were randomly divided into 3 groups:standard group, the trauma group and the dexamethasone treatment group.Parameters about pia mater microcirculation and hemorheology were measured at different interval.The results showed that high-dose dexamethasone had significant role of extending pia mater microartery,increasing pia mater blood flow-rate,reducing whole blood viscosity,erythrocyte aggregation,ESR,HCT,and increasing erythrocyte deformability.The results suggest that high-dose dexamethasone can improve cerebral microcirculation and hemorheology in rabbits with cerebral trauma.