Synthesis of N-[(3S)-2,6-dioxo-1-(2-phenylethyl)-3-piperidinyl]-(2S)-2-methylbutanamide ((-)-julocrotine) |
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| Authors: | Silva Luciano L Joussef Antonio C |
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| Institution: | Departamento de Qui?mica, Universidade Federal de Santa Catarina , Floriano?polis, SC 88040-900, Brazil. |
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| Abstract: | The total synthesis of (-)-julocrotine (1) starting from l-glutamic acid in 41% overall yield is described. The methodology utilizes protection, deprotection, and regioselection (carbonyl differentiation via oxazolidinone) protocols, and glutarimide ring formation is the key step. |
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