| 夹竹桃甙对Na~+、K~+-ATP酶抑制的动力学研究 |
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| 引用本文： | 潘彬,陈锐群,潘德济,顾天爵. 夹竹桃甙对Na~+、K~+-ATP酶抑制的动力学研究[J]. 复旦学报(医学版), 1990, 0(6) |
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| 作者姓名： | 潘彬 陈锐群 潘德济 顾天爵 |
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| 作者单位： | 上海医科大学基础医学部生物化学教研室(潘彬，陈锐群)，药学院天然药物化学教研室(潘德济)，上海医科大学基础医学部生物化学教研室(顾天爵) |
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| 摘 要： | 本文对夹竹桃甙抑制Na~+、K~+-ATP酶的动力学作了探讨,并与乌本甙的作用进行了比较。结果表明:夹竹桃甙抑制Na~+、K~+-ATP酶,在Na~+、K~+浓度改变对均为非竞争性抑制,Na~+/K~+比例6:1时,为混合性抑制,而ATP对夹竹桃甙的作用几无影响。
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| 关 键 词： | 夹竹桃甙 Na~+、K~+-ATP酶 抑制剂 |
KINETIC STUDIES ON OLEANDRIN INHIBITION OF Na~+, K~+-ATPase |
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| Pan Bin,Chen Euiqun,Pan Deji,Gu Tianjue. KINETIC STUDIES ON OLEANDRIN INHIBITION OF Na~+, K~+-ATPase[J]. Fudan University Journal of Medical Sciences, 1990, 0(6) |
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| Authors: | Pan Bin Chen Euiqun Pan Deji Gu Tianjue |
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| Abstract: | The kinetics and mechanism of inhibition of Na+, K+-ATPase by oleandrin were studied. Characteristics of its inhibitory action on Na+, K+-ATPase were compared with those of onabain. Kinetic analysis revealed oleandrin to be a non-competitive inhibitor with respect to Na+, K+, and showed mixed inhibition with respect to Na+/K+(6:1). ATP was without affect on oleandrininhibition of Na+, K+-ATPase. |
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| Keywords: | oleandrin Na+ K+-ATPase inhibitor |
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