广州地区女性泌尿生殖道感染者解脲脲原体体外耐药变化的研究

目的控制非淋菌性尿道炎的蔓延,为合理使用抗生素提供依据。方法对广州地区女性泌尿生殖道感染患者解脲脲原体(UU)的药物敏感性进行了为期4年(2000年1月~2003年12月)的连续观察。对每年分离的UU进行10种常用抗生素的药敏检测,测定其对以上药物的敏感度及耐药率。结果多西环素、米诺环素和阿奇霉素的药物敏感度无明显改变;交沙霉素的耐药率显著上升,耐药率从2000年的7.6%上升至2003年的21.0%。结论UU的耐药趋势正逐渐增强;喹诺酮类药物的高耐药率表明该类药物在非淋菌性尿道炎治疗方面要严格控制和选择;对于UU感染的患者应根据药敏结果,合理选择抗菌药物。

The Study on Drugs Susceptibility of Ureaplasma Urealyticum Isolated from Women with Genitourinary Infection in Guangzhou

Objective For slowing down the increasing speed of the nongonococcal urethritis and getting it be controlled, providing the basis to use the antibiotic reasonably.Methods Ureaplasma urealyticum drug susceptibility has been monitored during the last four years, from 2000 to 2003.Ten drugs susceptibility have been tested for Ureaplasma urealyticum isolated in every year.Results The Doxycycline,minocycline and Azithromycin showed sensitive response in susceptibility test. The resistant rate of josamycin increased to a high level,from 7.6% in 2000 to 21.0% in 2003.Conclusion The tendency of drug resistant in Ureaplasma urealyticum was growing year by year. The ciprofoxacin showed a highly resistant in drug susceptibility test for Ureaplasma urealyticum isolates. To treat the infected patients with Ureaplasma urealyticum,we must select the antibiotics rationally according to the drug susceptibility test.