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| 盐酸地尔硫(艹卓)延迟释放片的制备 | |
| 引用本文： | 纪立伟,范田园,陈桂兰,魏树礼. 盐酸地尔硫(艹卓)延迟释放片的制备[J]. 中国医药工业杂志, 2005, 36(3): 155-157 |
| 作者姓名： | 纪立伟 范田园 陈桂兰 魏树礼 |
| 作者单位： | 1. 卫生部北京医院药剂科,北京,100730 2. 北京大学药学院药剂学教研室,北京,100083 3. 河北医科大学药剂学教研室,河北,石家庄,050017 |
| 摘 要： | 以盐酸地尔硫(艹卓)为模型药物,不溶性乙基纤维素为阻滞材料,Eudragit L100及S100为致孔剂,采用薄膜包衣法制得延迟释放片.结果表明,阻滞层包衣材料的配比和增塑剂柠檬酸三乙酯的用量是影响延迟效果的主要因素. |
| 关 键 词： | 地尔硫(艹卓) 延迟释放片 体外释放 包衣 |
| 文章编号： | 1001-8255(2005)03-0155-03 |
| 修稿时间： | 2003-12-15 |
Preparation of Delayed-released Tablets of Diltiazem Hydrochloride |
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| JI Li-Wei,FAN Tian-Yuan,Chen Gui-lan,WEI Shu-li. Preparation of Delayed-released Tablets of Diltiazem Hydrochloride[J]. , 2005, 36(3): 155-157 | |
| Authors: | JI Li-Wei FAN Tian-Yuan Chen Gui-lan WEI Shu-li |
| Abstract: | The delayed-release tablets were prepared by film-coating technology using diltiazem hydrochloride asmodel drug, insoluble ethylcellulose as retarding material and Eudragit L100 and S100 as porous agents. The results showedthat the ratio of the coating material of retarding film and the amount of plasticizer triethyl citrate were the main influenceeffects of the delayed release. |
| Keywords: | diltiazem delayed-release tablets in vitro release film-coating |
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