| STUDIES ON THE PREVENTIVE ACTION OF OLEANOLIC ACID ON EXPERIMENTAL CIRRHOSIS |
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| 作者姓名： | 韩德五 马学惠 赵元昌 尹镭 冀春萱 |
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| 作者单位： | Laboratory of Hepatic Diseases Shanxi Medical College，Laboratory of Hepatic Diseases，Shanxi Medical College，Laboratory of Hepatic Diseases，Shanxi Medical College，Laboratory of Hepatic Diseases，Shanxi Medical College，Laboratory of Hepatic Diseases，Shanxi Medical College |
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| 摘 要： | The preventive actions of oleanolic acid(OA) on experimental cirrhosis have been stu-died.Results indicate that the development ofcirrhosis in rats induced by the injection ofCCl_4 and dietetic injury may be prevented byOA.It was found that the necrosis and degene-ration of the liver cells in the oleanolic acidtreated rats were less severe than those of CCl_4controls.Also the infiltration of lipid and fibro-genesis in the liver were inhibited,andSGPT level was shown to be decreased in OArats.Moreover,oleanolic acid promoted rege-neration of the liver in partially hepatectomizedrats.OA may be a rational drug for treatmentof chronic liver diseases and prevention of cirr-hosis.The mechanism of action of OA was dis-cussed.
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