| 右半结肠癌中p53，ki-67的表达及与分化程度及Ducks分期的关系 |
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| 引用本文： | 李铁灵,郭海峰,杜晓宏. 右半结肠癌中p53，ki-67的表达及与分化程度及Ducks分期的关系[J]. 牡丹江医学院学报, 2007, 28(4): 17-19 |
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| 作者姓名： | 李铁灵 郭海峰 杜晓宏 |
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| 作者单位： | 1. 牡丹江医学院,黑龙江,牡丹江,157011
2. 吉林大学第一医院,吉林,长春,130021 |
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| 基金项目： | 黑龙江省卫生厅科研项目 |
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| 摘 要： | 目的：研究p53，ki-67在右半结肠癌组织中的表达，初步探讨两者与结肠癌分化程度和Ducks分期的关系方法：统计89例右半结肠癌病人肿瘤p53，ki-67的表达，结合临床病理进行分析。结果：右半结肠癌p53蛋白阳性表达与结肠癌分化程度和Ducks分期有关，ki-67蛋白的表达强度与Ducks分期有关。结论：检测p53、ki-67的表达对临床治疗及预后有一定的指导意义。
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| 关 键 词： | 右半结肠癌 P53 KI-67 Duck分期 分化程度 |
RESARCH OF P53 ,KI- 67 PROTEIN EXPRESSION IN RIGHT-SIDED COLON CANCER TISSUE AND THEIR RELATIONSHIP WITH HISTOLOGICAL DIFFERENTIATION AND DUKE S STAGE |
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| Li tieling et al. RESARCH OF P53 ,KI- 67 PROTEIN EXPRESSION IN RIGHT-SIDED COLON CANCER TISSUE AND THEIR RELATIONSHIP WITH HISTOLOGICAL DIFFERENTIATION AND DUKE S STAGE[J]. Journal of Mudanjiang Medical College, 2007, 28(4): 17-19 |
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| Authors: | Li tieling et al |
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| Affiliation: | Mudan jiang Medical College Heilongjiang Mudangjiang 157011 |
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| Abstract: | To research the expression of p53 , ki -67 protein in right-sided colon cancer tissue and primarily research on their relation with histological differentiation and Dukes＇stage. Methods：Expression of p53 , ki-67 protein level was determined by immunohistochemistry technique in 89 patients with right-sided colon cancer and analyzed the following clinicopathological factors ： histological differentiation and Dukes＇stage. Results：The expression of p53 protein has correlation with histological differentiation and Dukes＇stage , meanwhile quantitively different of ki-67 protein expression are correlated with Dukes＇stage in right-sided colon cancer tissue. Conclusion：Assessing the expression of p53 ,ki-67 protein could be useful for clinical treatment and to evaluate prognosis. |
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| Keywords: | p53 ki-67 |
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