| 双核微核法检测煤尘遗传毒性的研究 |
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| 引用本文： | 赵一军 吴中亮. 双核微核法检测煤尘遗传毒性的研究[J]. 癌变．畸变．突变, 1995, 7(1): 51-53 |
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| 作者姓名： | 赵一军 吴中亮 |
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| 作者单位： | 山西太原医学院卫生毒理教研室，广州医学院卫生学教研室 |
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| 摘 要： | 用双核微量核法对三种煤尘亚硝化前后的致突变性进行检测，结果未经亚硝化时，三种煤尘均呈现致突变作用；而在酸性条件下被亚硝化后，二种烟煤表现出了致突变性能。试验提示，在检测煤尘致突变作用中，体外细胞双核微核法的灵敏度高于传统微核法。
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| 关 键 词： | 双核微核法 煤尘 致突变性 胃肿瘤 遗传毒理 |
STUDIES ON THE GENOTOXICITY OF EXTRACT OF COALDU8T WITH CYTOKINESIS BLOCKED MICRONUCLEUS ASSAY |
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| Abstract: | The mutagenecity of three nitrosated and non nitrosated coal dust extracts wastested with the cytokinesis bolcked micronucleus assay. The results showed that three coaldust extracts were non mutagenic when they had not been nitrosated, but tow bituminouscoal of them showed mutagenecity after they were nitrosated under acidic conditions. Thesefindings indicated that the sensitivity of cytokinesis blocked micronucleus assay is higherthan the assay without cytokinesis blockage. |
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| Keywords: | cytokinesis blocked micronucleus assay coal dust gastfic cancer mutagenecity |
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