中医药及微波热疗联合化疗治疗卵巢癌腹水的临床疗效

目的:探讨中医药及微波热疗联合化疗对卵巢癌腹水的临床疗效及安全性.方法:将80例卵巢癌腹水患者作为研究对象,随机分成对照组和治疗组,每组各40例.对照组单纯进行化疗,而治疗组在对照组的基础上联合中医药及微波热疗.结果:全部患者顺利完成治疗,治疗后在中医症候改善方面对照组总有效27例(67.5％),治疗组总有效36例(90％),两组差异有统计学意义(P<0.05);治疗后患者的腹围、体重都较治疗前减小,差异有统计学意义(P<0.05);与对照组比较,治疗组腹围明显减小,差异有统计学意义(P<0.05);治疗后两组的肿瘤标志物水平都有不同程度的下降,而治疗组CA125,HE4降低明显,差异有统计学意义(P<0.05).结论:中医药及微波热疗联合化疗对卵巢癌腹水的临床疗效明显,能够有效控制疾病的进展,并且毒副作用低,为治疗卵巢癌腹水提供一定的临床依据.

Clinical effect of traditional Chinese medicine and microwave hyperthermia combined with chemotherapy in the treatment of ovarian cancer ascites

Objective: To study the clinical efficacy and safety of traditional Chinese medicine and microwave hyperthermia combined with chemotherapy in the treatment of ovarian cancer and ascites. Methods: Eighty cases of ovarian cancer ascites were randomly divided into two groups: a control group and a treatment group, 40 cases in each group. The control group was treated with chemotherapy alone, while the treatment group was combined with traditional Chinese medicine and microwave hyperthermia on the basis of the control group. Results: All patients completed the treatment successfully, after treatment, the total effective was 27 cases (67.5％) in the control group, the treatment group was 36 (90％), the difference was statistically significant (P<0.05). After the treatment, the patient's abdominal circumference and weight decreased than before treatment, the difference was statistically significant (P<0.05); the abdominal circumference in the treatment group decreased significantly compared with the control group, the difference was statistically significant (P<0.05); the levels of tumor markers in the two groups after treatment decreased in different degrees. The treatment group in reducing CA125, HE4 on the curative effect was prominent, the differences were statistically significant (P<0.05), which showed that the treatment group was more effective than chemotherapy alone in reducing the tumor marker. Conclusion:Traditional Chinese medicine and microwave hyperthermia combined with chemotherapy in the treatment of ovarian cancer has obvious curative effect, which can effectively control the progress of the disease, and the low side effect, and provide some clinical evidence for the treatment of ovarian cancer with ascites.