| 人工血红蛋白的最新应用进展 |
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| 引用本文： | 孙婷,曹斌,孟庆贵,张磊. 人工血红蛋白的最新应用进展[J]. 国际输血及血液学杂志, 2017, 40(2). DOI: 10.3760/cma.j.issn.1673-419X.2017.02.002 |
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| 作者姓名： | 孙婷 曹斌 孟庆贵 张磊 |
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| 作者单位： | 1. 中国医学科学院北京协和医学院血液学研究所血液病医院,天津,300020;2. 山东万安药业有限公司,山东东营,257067 |
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| 基金项目： | 国家自然基金面上项目,天津市自然基金面上项目(15JCZDJC35800)National Natural Science Foundation of China,Natural Science Foundation of Tianjin |
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| 摘 要： | 输血治疗是临床治疗中不可或缺的重要手段.从20世纪70年代开始,随着血液制品的大量临床应用,使其安全性问题逐渐进入人们的视线.全球性的血液储备不足,血液制品相关疾病的传播等问题促使研究者积极开发更加安全、有效的人工血液,现阶段的研究主要聚焦于某种血液细胞成分的功能替代物的研发.自1930年以来,人们在替代红细胞功能的人工载氧体,如人工血红蛋白(Hb)领域,进行了大量的基础研究和临床试验.笔者拟主要针对以Hb为基础的人工载氧体和以蚯蚓血红蛋白(Hr)为基础的人工载氧体的最新应用进展进行阐述.
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| 关 键 词： | 输血 血液代用品 血红蛋白 临床试验 |
New progress in application of artificial hemoglobin |
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| Sun Ting,Cao Bin,Meng Qinggui,Zhang Lei. New progress in application of artificial hemoglobin[J]. International Journal of Blood Tranfusion and Hematology, 2017, 40(2). DOI: 10.3760/cma.j.issn.1673-419X.2017.02.002 |
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| Authors: | Sun Ting Cao Bin Meng Qinggui Zhang Lei |
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| Abstract: | Blood transfusion therapy is an indispensable mean of clinical treatments.Since the 1970s,the extensive use of blood products and security issues had gradually come into people's attention.Global lack of blood reserves,the spread of blood-related diseases and other issues prompted researchers to actively develop more safe and effective artificial blood,and at this stage it mainly refers to the functional substitutes of certain blood cell components.Since 1930,people have carried out a large number of basic researchs and clinical trials in the field of artificial oxygen carriers,such as artificial hemoglobin (Hb).Here,we introduced the new progress of Hb-based artifical oxygen carriers and earthworm hemoglobin (Hr)-hased artitical oxygen carriers. |
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| Keywords: | Blood transfusion Blood substitutes Hemoglobins Clinical trial |
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