| 杀伤细胞免疫球蛋白样受体对造血干细胞移植的影响 |
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| 引用本文： | 张凯宁,苏丽萍. 杀伤细胞免疫球蛋白样受体对造血干细胞移植的影响[J]. 国际输血及血液学杂志, 2017, 40(3). DOI: 10.3760/cma.j.issn.1673-419X.2017.03.016 |
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| 作者姓名： | 张凯宁 苏丽萍 |
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| 作者单位： | 1. 山西医科大学研究生学院,太原,030001;2. 山西医科大学附属肿瘤医院血液科,太原,030013 |
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| 基金项目： | 太原市科技项目(12016909)Taiyuan Science and Technology Project |
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| 摘 要： | 自然杀伤(NK)细胞表面的杀伤细胞免疫球蛋白样受体(KIR),可通过与人类白细胞抗原(HLA)相互作用,影响NK细胞活性,进而影响异基因造血干细胞移植(allo-HSCT)的预后.在去T淋巴细胞allo-HSCT中,KIR/HLA错配的异源反应性NK细胞,在抗急性髓细胞白血病(AML)中发挥了重要作用;而未去T淋巴细胞allo-HSCT中,KIR/HLA错配对患者预后影响迥异.研究者提出,在自体造血干细胞移植(auto-HSCT)中也存在移植物抗白血病(GVL)效应,并且患者存在不同KIR对移植预后影响不同.笔者拟就KIR/HLA错配在造血干细胞移植中作用的研究进展进行综述.
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| 关 键 词： | 受体,自然杀伤细胞 移植免疫学 白血病 杀伤细胞免疫球蛋白样受体 |
Effects of killer-cell immunoglobulin-like receptor on hematopoietic stem cell transplantation |
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| Zhang Kaining,Su Liping. Effects of killer-cell immunoglobulin-like receptor on hematopoietic stem cell transplantation[J]. International Journal of Blood Tranfusion and Hematology, 2017, 40(3). DOI: 10.3760/cma.j.issn.1673-419X.2017.03.016 |
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| Authors: | Zhang Kaining Su Liping |
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| Abstract: | Interactions between killer-cell immunoglobulin-like receptor (KIR) and human leukocyte antigen (HLA) influence activity of natural killer (NK) cell,and then affect the allogeneic hematopoietic stem cell transplantation(allo-HSCT).In T cell-deplete allo-HSCT,alloreactive NK cells with mismatched KIR/HLA play a major role in acute myeloid leukemia (AML).On the other hand,the correlations between KIR/HLA mismatching and T cell-replete allo-HSCT have reported various results.Studies have suggested that graft versus leukemia (GVL) effect is also present in autologous hematopoietic stem cell transplantation (auto-HSCT).KIR/HLA mismatching plays an important role in auto-HSCT as well.This article mainly elaborates the function of KIR/HLA mismatching in hematopoietic stem cell transplantation. |
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| Keywords: | Receptor,natural killer cell Transplantation immunology Leukemia Killer cell immunoglobulin-like receptors |
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