LDL-c/HDL-c对女性2型糖尿病患者颈动脉斑块形成的影响

目的:评估LDL-c/HDL-c(L/H)在女性2型糖尿病患者颈动脉斑块形成中的影响.方法:根据颈动脉彩色多普勒超声检查结果,将210例女性2型糖尿病患者,分为颈动脉斑块组100例,对照组(无颈动脉斑块)110例,收集一般临床资料以及颈动脉斑块的危险因素进行比较,采用单因素分析、logistic回归分析、绘制ROC曲线等方法评估L/H在临床中的优势.结果:两组之间入组人群年龄,病程,收缩压,HbA1c,UA,LDL-c,HDL-c及L/H差异均有统计学意义(P<0.05).两组BMI,TC,TG和舒张压比较差异无统计学意义(P>0.05);通过logistic回归分析,剔除混杂因素,年龄,HbA1c,UA,L/H的OR值分别为1.128,1.469,1.005,1.952,提示均为颈动脉斑块形成的危险因素.L/H的ROC曲线下面积(0.689)优于LDL-c(0.571),差异有统计学意义.结论:L/H在糖尿病血管病变的评估中,更加全面和准确,价值更高.

Effect of LDL-c/HDL-c in formation of carotid artery plaque in female patients with type 2 diabetes mellitus

Objective: To evaluate the significance of LDL-c/HDL-c (L/H) in formation of carotid artery plaque in female patients with type 2 diabetes mellitus. Methods: A total of 210 female patients with type 2 diabetes mellitus were divided into two groups: the experimental group consists of 100 cases who had carotid artery plaque and the control group included 110 cases without carotid artery plaque according to results of color Doppler ultrasound in carotid artery. The general clinical data and risk factors of carotid artery plaque were collected and compared; The clinic advantages of LDL-c/HDL-c were evaluated by single factor analysis, logistic regression analysis, receiving the ROC curves, and so on. Results: There were statistical differences between the two groups in age, the course of disease, the systolic pressure, HbA1c, UA, LDL-c, HDL-c and L/H (P<0.05). There was no significant difference in their BMI, TC, TG and diastolic blood pressure (P>0.05). With the method of rejecting confounding factors and with the help of logistic regression analysis, OR values of ages, HbA1c, UA and LDL-c/HDL-c were 1.128, 1.469, 1.005 and 1.952 respectively, which indicated they were risk factors in developing carotid artery plaque. The area under the ROC curve of LDL-c/HDL-c was 0.689 and that of LDL-c was 0.571, showing that LDL-c/HDL-c was better than LDL-c as an evaluation parameter. Conclusion: More comprehensiveness, accuracy and value can be achieved when applying L/H to evaluating diabetic angiopathy.