骨髓基质细胞相关细胞因子调控移植物抗宿主病的研究进展

异基因造血干细胞移植(allo-HSCT)为治疗血液系统恶性疾病的有效手段.约50％患者在接受allo-HSCT后会发生不同程度的移植物抗宿主病(GVHD),这可能严重影响接受allo-HSCT患者的预后及生活质量.因此,关于allo-HSCT后GVHD的发生机制及防控措施为目前allo-HSCT相关研究领域的热点.造血微环境在allo-HSCT后造血重建及GVHD发生、发展中,均发挥重要作用,特别是关于骨髓基质细胞相关细胞因子与GVHD关系的研究,更是allo-HSCT相关研究领域的热点.监测骨髓基质细胞相关细胞因子表达水平变化,对GVHD的早期预测及早期干预具有重要作用.为了阐明allo-HSCT后GVHD的相关发生机制,笔者拟就骨髓基质细胞相关细胞因子在GVHD发生、发展中表达水平的变化及其作用进行综述.

Advances in bone marrow mesenchymal cell related cytokines in regulating graft versus host disease

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective therapeutic option for curing hematologic malignancy.But approximately 50 ％ of patients would suffer from graft versus host disease (GVHD) after allo-HSCT,which was significantly correlated with patients' prognosis.Therefore,how to prevent and treat GVHD is a research hotspot in allo-HSCT field.Hematopoietic microenvironment is significantly correlated with occurrence and progression of GVHD.Recent evidences have demonstrated that cytokine related to bone marrow mesenchymal cell is associated with patients' prognosis,and the observations pointing to these cytokines will open up new possibilities with respect to treatment of GVHD.In order to figure out the mechanisms of GVHD,the authors will summarize the current understanding of bone marrow mesenchymal cell related cytokine in GVHD.