| 腺病毒载体在病毒性疫苗中的研究进展 |
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| 引用本文： | 刘晶晶. 腺病毒载体在病毒性疫苗中的研究进展[J]. 国际生物制品学杂志, 2017, 40(5). DOI: 10.3760/cma.j.issn.1673-4211.2017.05.010 |
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| 作者姓名： | 刘晶晶 |
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| 作者单位： | 中国食品药品检定研究院虫媒病毒疫苗室,北京,100050 |
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| 摘 要： | 基于腺病毒载体安全性好、诱导体液和细胞免疫效率高、容纳外源基因片段大、易于大规模培养等优点,其为构建新型疫苗提供了新的思路与手段.此文简要综述了腺病毒的生物学特性、腺病毒载体的构建策略、以腺病毒为载体构建病毒性疫苗的研究现状和目前存在的问题等,重点介绍了已经进入临床试验的腺病毒载体病毒性疫苗的研究进展.
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| 关 键 词： | 腺病毒,人 遗传载体 病毒疫苗 |
Progress on adenovirus vector research in viral vaccines |
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| Liu Jingjing. Progress on adenovirus vector research in viral vaccines[J]. International Journal of Biologicals, 2017, 40(5). DOI: 10.3760/cma.j.issn.1673-4211.2017.05.010 |
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| Authors: | Liu Jingjing |
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| Abstract: | With its good safety,high efficiency in inducing humoral as well as cellular immune responses,capacity to contain long foreign gene,and feasibility of large scale culture,adenovirus vector provides a new means for vaccine development.This paper summarizes the characteristics of adenovirus vector,its construction strategies,current study on adenovirus-vectored viral vaccines and present problems,focusing on development of recombinant adenovirus viral vaccines that have entered clinical trials. |
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| Keywords: | Adenoviruses,human Genetic vectors Viral vaccines |
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