依达拉奉、丙戊酸钠联合治疗脑卒中后继发性癫痫的疗效

目的:探讨依达拉奉、丙戊酸钠联合治疗对脑卒中后继发性癫痫(PSE)的疗效及血清神经元特异性烯醇化酶(NSE)的影响。方法:82例PSE患者随机分为观察组和对照组各41例,均给予口服丙戊酸钠缓释片,观察组还给予静脉滴注依达拉奉1周。比较2组治疗前后癫痫发作次数、发作持续时间、痫样放电、累及导联数及血清(NSE)水平,并记录2组不良反应情况。结果:对照组和观察组总有效率分别为80.5%、95.1%,观察组高于对照组(P0.05)。治疗后2组癫痫发作次数、每次发作持续时间均显著减少,其中治疗后观察组癫痫发作次数、每次发作持续时间低于对照组(P0.05)。与治疗前比较,2组治疗后痫样放电、累及导联数均呈下降趋势,其中观察组痫样放电、累及导联数下降更明显(P0.05)。2组治疗后血清NSE均降低,观察组治疗1月血清NSE低于对照组(P0.05)。2组不良反应发生率比较差异无统计学意义(P0.05)。结论:依达拉奉联合丙戊酸钠能够有助于控制PSE癫痫症状,提高疗效,且安全性高。

Clinical Efficacy of Edaravone Combined with Sodium Valproate in Treatment of e Epilepsy Patients with Previous Stroks

Objective:To explore the effects of Edaravone combined with Sodium Valproate treatment on clinical outcome and serum neuron-specific enolase (NSE) level of post stroke epilepsy (PSE) patients.Methods:A total of 82 cases of PSE patients were divided into groups of control and observation with 41 in each.The both groups were given oral Sodium Valproate sustained-release tablets,and the observation group were given intravenous infusion of Edaravone for 1 week.The seizure frequency,duration of attacks,discharge of epileptic discharges,lead number and serum NSE levels were compared between the two groups before and after the treatment,and the adverse reactions were recorded.Results:The total effective rates of the control group and observation group were 80.5％,and 95.1％ respecively with a significant difference (P＜0.05).After the treatment,the frequency of seizures and duration of each attack were significantly reduced,espeially in the observation group (P＜0.05).Afer the treatment,the numbers of the lead in the 2 groups were decreased and more significantly in the observation group (P＜0.05),and so the the serum levels of NSE (P＜0.05).No significant difference in adverse reactions rate was evident between the two groups (P＞0.05).Conclusion:Edaravone combined with Sodium Valproate can be effective for controlling PES epilepsy symptoms with a high safety.