| TRPV3与皮肤功能障碍的相关研究进展 |
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| 引用本文： | 叶蕾,梁碧玉,何玉清. TRPV3与皮肤功能障碍的相关研究进展[J]. 国际遗传学杂志, 2017, 40(1). DOI: 10.3760/cma.j.issn.1673-4386.2017.01.010 |
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| 作者姓名： | 叶蕾 梁碧玉 何玉清 |
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| 作者单位： | 1. 广东医科大学流行病与卫生统计学教研室,东莞,523808;2. 广东医科大学医学系统生物学研究所,东莞,523808 |
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| 基金项目： | Natural Science Foundation of Guangdong Province，Talents Recruitment Program of Guangdong Province " Yangfan Plan"，International Cooperation Program of Guangdong Province Science and Technology Department (2013B051000080)广东省自然科学基金，广东省扬帆计划引进紧缺拔尖人才项目，广东省科技厅国际合作项目 |
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| 摘 要： | 瞬时感受器电位香草素受体亚家族3 (transient receptor potential vanilloid 3,TRPV3)是存在于细胞膜上的一类非选择性阳离子通道蛋白,其主要在人体皮肤角质细胞表达,在介导钙离子传递、影响表皮角质细胞增殖分化、参与炎症反应以及调节温度觉、痒觉和痛觉等多种生物过程中发挥重要作用.本文综述了TRPV3与遗传角化性皮肤病、皮肤瘙痒、皮肤炎症和疼痛的相关研究进展,为揭示TRPV3基因在皮肤功能障碍中的作用机制提供理论依据.
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| 关 键 词： | 瞬时感受器电位香草素受体亚家族3 皮肤功能 感觉信号传导 钙通道 |
Progress in the correlation studies of TRPV3 and skin dysfunction |
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| Ye Lei,Liang Biyu,He Yuqing. Progress in the correlation studies of TRPV3 and skin dysfunction[J]. International JOurnal of Genetics, 2017, 40(1). DOI: 10.3760/cma.j.issn.1673-4386.2017.01.010 |
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| Authors: | Ye Lei Liang Biyu He Yuqing |
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| Abstract: | Transient receptor potential vanilla receptor and family 3 (transient receptor potential vanilloid 3,TRPV3) is a nonselective cation channels protein on the cell membrane,and mainly expressed in human skin keratinocytes.TRPV3 is involved in mediating calcium ion transfer,influences epidermis keratinocytes proliferation and differentiation,participates in the inflammatory response,and plays an important role in adjusting temperature feel,paining feel,itching feel of skin,and other biological processes.In this review,we summarized the studies on association of TRPV3 with genetic keratoderma,skin itch,inflammation and pain related research progress,to reveal TRPV3 mechanism of the role of genes in skin disorders.We will provide the scientific theoretical basis for revealing the functional mechanism of TRPV3 in skin dysfuction. |
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| Keywords: | TRPV3 Skin function Sensory transmission Ca2+ channel |
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