丁苯酞与阿托伐他汀治疗急性脑梗死的临床疗效及对血液流变学的影响

目的:探究丁苯酞联合阿托伐他汀对急性脑梗死患者神经功能及血液流变学的影响。方法:将124例急性脑梗死患者随机分为对照组和试验组各62例。2组均给予常规补液治疗,并给予阿司匹林和阿托伐他汀片口服;试验组加用静脉滴注丁苯酞氯化钠注射液,疗程均为14 d。分别于治疗7、14 d采用NIHSS评分和BI评分评价2组的恢复情况;治疗14 d后,检测2组的血液流变学指标;比较2组的不良反应;治疗后90、180 d回访。结果:治疗14 d后,试验组的NIHSS评分、BI评分优于对照组(P<0.05);试验组的总有效率和痊愈率高于对照组(P<0.05);试验组的血液流变学指标恢复也优于对照组(P<0.05);2组不良反应比较差异无统计学意义(χ2=0.532,P=0.498);2组治疗后90、180 d,BI评分优于治疗前(P<0.05),且试验组优于对照组(P<0.05)。结论:丁苯酞联合阿托伐他汀治疗急性脑梗死患者安全、有效。

Effects of Butylphthalide Combined with Atorvastatin Treatment on Neurologic Impairment and Hemorheology in Patients with Acute Cerebral Infarction

Objective:To investigate therecovery of neurological deficits and hemorheology treated with butylphthalide and atorvastatin in patients with acute cerebral infarction.Methods:Total 124 acute stroke patients were collected in this study,62 patients in control group and 62 patients in treatment group.All patients were treated with routine therapy,including aspirin and atorvastatin for 14 days.Patients in the treatment group were treated with the routine treatment and butylphathlide for 14 days.NIHSS score and BI score were used to evaluate the recovery of neurological function of the two groups after 7 days and 14 days.The hemorheology indexes were detected after 14 days,and the adverse reactions were recorded.The follow-up was performed at 90 days and 180 days after treatment.Results:14 days after the treatment,the NIHSS score and BI score of the patients in the treatment group were significantly better than those in the control group (P＜0.05).The total efficiency and the recovery rate of treatment group were significantly higher than-those in the control group (P＜0.05).The treatment group showed better hemorheology indexes than the control group(P＜0.05).Tho were no significant difference in the adverse reactions between the two groups (x2=0.532,P=0.498).BI scores was improved at 90 and 180 days after treatment in both the groups (P＜0.05);and the treatment group patients were significantly better than the control group (P＜0.05).Conclusion:Butylphthalide combined with atorvastatin is safe and effective for acute cerebral infarct patients.