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| 六白白疕巴布剂药物提取正交实验研究 | |
| 引用本文： | 张伟,张云丽,杨一丁,高文勇,杨文婷.六白白疕巴布剂药物提取正交实验研究[J].齐鲁药事,2010,29(11):644-646. |
| 作者姓名： | 张伟 张云丽 杨一丁 高文勇 杨文婷 |
| 作者单位： | 1. 青岛市海慈医疗集团,山东,青岛,266033 2. 青岛市立医院,山东,青岛,266012 3. 青岛市卫生学校,山东,青岛,266071 |
| 基金项目： | 青岛市科技发展项目-中医类，青岛市医药科研指导计划项目 |
| 摘 要： | 目的优选六白白疕巴布剂药物提取液制备的最佳提取工艺.方法以高效液相色谱法测定组方主要药物甘草的主要有效成分甘草酸含量为指标,采用正交试验设计法,对乙醇浓度,乙醇用量(倍),提取时间(h),提取次数等因素进行考察.结果影响因素从大到小依次为提取次数>乙醇用量>提取时间>乙醇浓度;其中提取次数影响最大.结论最佳提取工艺条件是每次用五倍药材量的50%乙醇,提取三次,每次提取时间40min. |
| 关 键 词： | 正交设计 六白白疕巴布剂 药物提取液 甘草酸 高效液相色谱法 |
Optimization of extraction conditions of Liubaibaibi Cataplasm by orthogonal |
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| ZHANG Wei,ZHANG Yun-li,YANG Yi-ding,GAO Wen-yong,YANG Wen-ting.Optimization of extraction conditions of Liubaibaibi Cataplasm by orthogonal[J].qilu pharmaceutical affairs,2010,29(11):644-646. | |
| Authors: | ZHANG Wei ZHANG Yun-li YANG Yi-ding GAO Wen-yong YANG Wen-ting |
| Institution: | (Qingdao Haici Medical Group,Qingdao 266033;1.Qingdao Municipal Hospital,Qingdao 266012;2.Medical School of Qingdao,Qingdao 266071) |
| Abstract: | OBJECTIVE To optimize the extraction process of Liubaibaibi Cataplasm.METHODS Using the orthogonal design,the content of glycyrrhizic acid was determined by HPLC to optimize the extraction process,The investigation factors were ethanol concentration,alcohol volume,extraction time and extract times.RESULTS Extraction of factors in decreasing order of extract timesalcohol volumeextraction timeethanol concentration;extract times was the most Important factor.CONCLUSION The best extraction process of Liubaibaibi Cataplasm was obtained as following：5 times of 50% alcohol,extraction for 3 times and 40min for each time. |
| Keywords: | Orthogonal design Liubaibaibi Cataplasm Extraction procedure Glycyrrhizic acid HPLC |
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