Transport of Apolipoproteins A-I and A-II by Human Thoracic Duct Lymph |
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| Authors: | David W. Anderson Ernst J. Schaefer Thomas J. Bronzert Frank T. Lindgren Trudy Forte Thomas E. Starzl Gary D. Niblack Loren A. Zech H. Bryan Brewer Jr. |
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| Affiliation: | Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20205 |
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| Abstract: | The daily transport of human plasma apolipoproteins A-I and A-II, triglyceride, and total cholesterol from the thoracic duct lymph into plasma was measured in two subjects before and three subjects after renal transplantation. Lymph triglyceride transport was ~83% of the daily ingested fat loads, whereas lymph cholesterol transport was consistently greater than the amount of daily ingested cholesterol. Lymph apolipoprotein transport significantly (P < 0.05) exceeded the predicted apolipoprotein synthesis rate by an average of 659±578 mg/d for apolipoprotein A-I and 109±59 mg/d for apolipoprotein A-II among the five subjects. It is estimated that 22-77% (apolipoprotein A-I) and 28-82% (apolipoprotein A-II) of daily total body apolipoprotein synthesis takes place in the intestine. |
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