| 黄芪多糖对哮喘小鼠气道高反应性及气道重塑的影响 |
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| 引用本文： | 俞建芬,顾淑萍,杨晓蕴.黄芪多糖对哮喘小鼠气道高反应性及气道重塑的影响[J].中药新药与临床药理,2011,22(4). |
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| 作者姓名： | 俞建芬 顾淑萍 杨晓蕴 |
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| 作者单位： | 1. 吴江市中医医院,江苏吴江,215221
2. 苏州大学附属儿童医院呼吸科,江苏苏州,215003 |
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| 摘 要： | 目的 观察黄芪多糖对哮喘小鼠气道高反应性及气道重塑的影响。方法 通过腹腔注射和雾化吸入卵蛋白(OVA)制备哮喘缓解期小鼠模型。使用黄芪多糖治疗2月后，末次给药后24 h观察小鼠气道反应性、肺泡灌洗液(BALF)中炎性细胞总数和细胞分类以及肺脏病理学变化。结果 黄芪多糖可以降低模型小鼠的气道高反应性，降低BALF中炎性细胞总数及嗜酸性粒细胞和中性粒细胞比例，改善支气管周围炎性细胞浸润、减轻气道壁胶原沉积和黏液分泌，减轻气道重塑。结论 黄芪多糖降低气道高反应性、减轻支气管周围嗜酸性粒细胞浸润以及改善气道重塑可能是其治疗哮喘的主要作用机制。
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| 关 键 词： | 黄芪多糖 哮喘 气道高反应性 嗜酸性粒细胞 气道重塑 小鼠 |
Effect of Astragalus Polysaccharides on Airway Hyperresponsiveness and Airway Remodeling in a Murine Model of Chronic Asthma |
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| YU Jianfen,GU Shuping,YANG Xiaoyun.Effect of Astragalus Polysaccharides on Airway Hyperresponsiveness and Airway Remodeling in a Murine Model of Chronic Asthma[J].Traditional Chinese Drug Research & Clinical Pharmacology,2011,22(4). |
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| Authors: | YU Jianfen GU Shuping YANG Xiaoyun |
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| Institution: | YU Jianfen 1,GU Shuping 1,YANG Xiaoyun 2 (1.Wujiang Hospital of Traditional Chinese Medicine,Wujiang 215221 Jiangsu,China,2.Deparment of Respiratory Diseases,Children's Hospital Affiliated to Soochow University,Suzhou 215003 Jiangsu,China) |
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| Abstract: | Objective To observe the effect of astragalus polysaccharides(APS)on hyperresponsiveness and airway remodeling in mice with chronic asthma.Methods BALB/c mice were sensitized with intraperitoneal injection of o-valbumin(OVA) to induce mice models of asthma in paracmasia.The intragastrical treatment of APS lasted two months,and 24 hours after the last administration,the airway hyper-responsiveness,inflammatory cell count and cell classification in bronchoalveolar lavage fluid(BALF),and lung histological exam... |
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| Keywords: | Astragalus polysaccharides Asthma Airway hyperresponsiveness Eosinophiles Airway remodeling Mice |
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