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| 藤茶提取物的抗肿瘤作用研究 | |
| 引用本文： | 周春权,姚欣,陈晓明,倪峰. 藤茶提取物的抗肿瘤作用研究[J]. 中药新药与临床药理, 2011, 22(6) |
| 作者姓名： | 周春权 姚欣 陈晓明 倪峰 |
| 作者单位： | 1. 福建省中医药研究院,福州,350003 2. 福建医科大学附属第二医院,福建泉州,362000 3. 福建卫生职业技术学院,福州,350101 |
| 基金项目： | 福建省发改委课题，福建省卫生教育联合攻关计划项目，福建省科技计划项目 |
| 摘 要： | 目的 观察藤茶提取物(FL0810)体内外抗肿瘤的作用.方法 采用S180腹水瘤模型观察FL0810体内抗肿瘤作用.应用四甲基偶氮唑蓝(MTT)法研究FL0810对肿瘤细胞体外增殖的影响.结果 FL0810能延长S180腹水瘤小鼠生存时间,与模型对照组相比有显著差异(P＜0.05)；FL0810对人乳腺癌细胞MDA-MB-231、MDA-MB-435、人前列腺癌细胞DU 145均有较强的体外增殖抑制作用,且呈现明显的剂量依赖性,抑制率随着药物浓度增加而增加；72 h半数抑制浓度(IC50)为别为208.71,226.14,150 μg/mL.结论 藤茶提取物在体内对5180的生长有一定的抑制作用,在体外对人乳腺癌和人前列腺癌有明显的抑制作用. |
| 关 键 词： | 藤茶提取物 抗肿瘤 四甲基偶氮唑蓝法 |
Studies on Anti-tumor Effect of Ampelopsis grossedentata Extracts |
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| ZHOU Chunquan,YAO Xin,CHEN Xiaoming,NI Feng. Studies on Anti-tumor Effect of Ampelopsis grossedentata Extracts[J]. Traditional Chinese Drug Research & Clinical Pharmacology, 2011, 22(6) | |
| Authors: | ZHOU Chunquan YAO Xin CHEN Xiaoming NI Feng |
| Affiliation: | ZHOU Chunquan1,YAO Xin1,CHEN Xiaoming3,NI Feng2(1.Fujian Institute of Traditional Chinese Medicine,Fuzhou 350003,China,2.Fujian Health Vocational & Technical College,Fuzhou 350101,3.The Second Affiliated Hospital,Fujian Medical University,Quanzhou 362000,China) |
| Abstract: | Objective To observe the anti-tumor effect of FL0810(an extract from Ampelopsis grossedentata) in vivo and in vitro.Methods S180 ascites tumor bearing mice model was used to observe inhibition of FL0810 on tumor growth in vivo.Then we applied methyl thiazolyl tetrazolium(MTT) method to study the effect of FL0810 on tumor cells proliferation in vitro.Results FL0810 could prolong the survival time of S180 ascites tumor bearing mice,and the difference was significant compared with the model control group(P < 0... |
| Keywords: | Ampelopsis grossedentata extracts Anti-tumor Methyl thiazolyl tetrazolium |
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