| 膝悦颗粒治疗大鼠佐剂性关节炎的实验研究 |
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| 引用本文： | 夏华玲,杜志谦,袁秀荣. 膝悦颗粒治疗大鼠佐剂性关节炎的实验研究[J]. 中药新药与临床药理, 2011, 22(4) |
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| 作者姓名： | 夏华玲 杜志谦 袁秀荣 |
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| 作者单位： | 1. 河南省正骨研究院,河南洛阳,471000
2. 上海中医药大学,上海,201203 |
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| 基金项目： | 河南省公益类科研院所预研项目,河南省重点科技攻关项目 |
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| 摘 要： | 目的 评价膝悦颗粒对大鼠佐剂性关节炎模型关节软骨的保护作用。方法 采用佐剂性关节炎大鼠动物模型,观察膝悦颗粒对关节肿胀指数、关节组织病理学和氧自由基等的影响。结果 与模型组比较,膝悦颗粒高、中剂量组对大鼠关节肿胀有显著抗炎作用(P＜0.05)。光镜观察显示,膝悦颗粒组滑膜充血、增生明显减轻,关节表面平整,结构清晰,无明显破坏。膝悦颗粒高、中剂量组能降低血清IL-6水平(P＜0.05),提高SOD水平(P＜0.05),降低血清NO水平(P＜0.05),低剂量组也能降低血清IL-6水平(P＜0.05)。结论 膝悦颗粒能消除关节肿胀,缓解炎症反应,具有保护关节软骨的作用。
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| 关 键 词： | 膝悦颗粒 佐剂性关节炎 肿胀 白细胞介素-6 超氧化物歧化酶 一氧化氮 |
Experimental Study on Xiyue Granules in Treating Adjuvant-induced Arthritis in Rats |
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| XIA Hualing,DU Zhiqian,YUAN Xiurong. Experimental Study on Xiyue Granules in Treating Adjuvant-induced Arthritis in Rats[J]. Traditional Chinese Drug Research & Clinical Pharmacology, 2011, 22(4) |
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| Authors: | XIA Hualing DU Zhiqian YUAN Xiurong |
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| Affiliation: | XIA Hualing 1,DU Zhiqian 1,YUAN Xiurong 2 (1.Institute of Orthopedics and Traumatology of Henan Province,Lu-oyang 471000,China,2.Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China) |
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| Abstract: | Objective To investigate the protective effects of Xiyue Granules(XG) on the articular cartilage of rats with adjuvant-induced arthritis.Methods Adjuvant-induced rat arthritis model was used for the study.The effects of XG on the swelling of joints,auricular pathology and oxygen free radicals were investigated.Results Compared with the model group,high-and middle-dosage XG had obvious anti-inflammation effect on the swollen joints(P < 0.05).In XG groups,the synovial congestion and hyperplasia of the joints ... |
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| Keywords: | Xiyue Granules Adjuvant-induced arthritis Swelling Interluekin-6 Superoxide dismutase Nitric oxide |
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