2型糖尿病初诊时慢性并发症相关因素分析及中日比较

目的调查初诊未治疗的2型糖尿病慢性并发症发病的相关因素,及与肥胖、高血压、高血脂等的关系,同时进行中日比较。方法选择对中日双方2709名初诊2型糖尿病患者,登记其生活背景,包括年龄、家族史、吸烟、饮酒、运动状况,同时检查眼底、心电图、血压,检测尿微量蛋白及神经传导速度。结果初诊2型糖尿病中方家族史、饮酒、运动状况少于日方(P<0.01),而高脂血症、高血压、肥胖患者较日方多(P=0.001,0.02,0.01);两组患者单纯糖尿病组、糖尿病合并高血压组、糖尿病合并高血脂组、糖尿病合并高血压及高血脂组,慢性并发症的患病率差异均无统计学意义(P>0.05);中日双方初诊时都有较高的慢性并发症发病率,两者差异没有统计学意义(P>0.05),但日方肾脏病变的发病率明显较中方高(P<0.01)。结论初诊2型糖尿病与高脂血症、高血压、肥胖等疾病及吸烟、饮酒、少动等不良生活习惯有密切的关系;中日双方初诊患者都有较高的慢性并发症发病率,日方肾脏病变的发病率更高。

Clinical association of chronic complication and comparison of Chinese and Japanese with newly diagnosed type 2 diabetes

Objective To investigate the associated factors of chronic complication,on obesity,hypertention,and hyperlipidemia and to compare between Chinese and Japanese in newly diagnosed type 2 diabetic patients.Methods There were 2709 patients with newly diagnosed type 2 diabetes in China and Japan.Their living background were registered,including age,family history,drinking,smoking,movement condition.As well as they receive ophthalmoscopy,ECG,blood pressure,urinary microalbumin and nerve conduction velocities.Results In newly diagnosed type 2 diabetes mellitus Chinese patients compared with Japanese patients,showed decreases in family history,drinking and movement condition(P<0.01),but showed increases in hyperlipidemia,hypertention and obesity(P=0.001,0.02,0.01).There were no difference in both group(P>0.05) no matter what the component is,such as pure diabetes mellitus,diabetes mellitus incorporated with hypertention,incorporated with hyperlipidemia and incorporated with hypertention and hyperlipidemia.Both Chinese and Japanese had higher and similar chronic complication suffering rate(P>0.05),except for Japanese,higher suffering rate in kidney(P>0.01).Conclusion Both the living habit such as hyperlipidemia,hypertention,and obesity and unhealthy habit,such as smoking,drinking,less-movement could markedly influence the newly diagnosed type 2 diabetic mellitus.Both group had higher chronic complication suffering rate,in diabetes nephropathy the Japanese higher suffering rate in kidney.