复方丹参注射液对小儿急性肾小球肾炎的影响

目的探讨复方丹参注射液对小儿急性肾小球肾炎(AGN)的疗效及其机制.方法用复方丹参注射液治疗AGN患儿30例(观察组),并与对照组进行比较.观测两组患儿水肿,高血压,血尿,蛋白尿的变化,检测其血清超氧化物歧化酶(SOD)活性和尿液丙二醛(MDA)含量.结果观察组患儿血清SOD活性显著增高(P＜0.01),高血压,水肿的缓解时间明显短于对照组(分别为P＜0.001和P＜0.01).其蛋白尿的转阴率也明显高于对照组(P＜0.05).结论复方丹参注射液治疗小儿急性肾小球肾炎效果良好,其机制与提高机体的抗氧自由基的能力有关.

Effects of Fufang Danshen Injection on Children's Acute Glomerulonephritis

Objective To research the curative effects and mechanism of injecting Fufang Danshen on children's acute glomerulonephritis (AGN).Method 30 cases with AGN were treated with the additional use of Fufang Danshen Injection in the observation group to compare its curative effects with 30 cases of control group.Clinical menifestation such as edema,hypertention,hematuria and proteinuria were observed,and the activities of serum superoxide dismutase (SOD) and the concentration of urine malondialdehyde (MDA) were measured.Results After treatment,in comparison with control group,it was showed that in observation group the activities of serum SOD was significantly higher(P<0.01).the time for remission of hypertension and edema were remarkably shorter (P<0.001 and P<0.01),and the regression rate of proteinuria was higher (P<0.05).Conclusion Fufang Danshen Injection has good curative effects on children's AGN,and the mechanism is related to increasing the abilities to resist oxygenmediated free radicals.