传染性非典型性肺炎患者肝功能变化

目的 探讨严重急性呼吸综合征(SARS)患者病程中出现肝功能异常的情况及可能的影响因素。方法 普通型SARS组91例,重型23例,普通肺炎组61例,入院后检测肝功能情况。结果 普通型SARS组肝功能异常发生率68.1%,显著高于普通肺炎组的24.6%(x~2=27.7,P<0.01),以丙氨酸氨基转移酶和天门冬氨酸氨基转移酶的轻、中度升高为主。重型患者肝功能异常发生率高达95.7%,年龄明显增大。结论 SARS患者发生肝功能损害的机会较大,可能与疾病本身有关,程度较轻,重型SARS的肝功能损害则与年龄有关。

Changes of liver function in patients with serious acute respiratory syndrome

Objectives To investigate the changes of liver function during the course of serious acute respiratory syndrome (SARS) and to explore its possible influence factors. Methods There were 91 patients with common SARS, and 23 patients with severe SARS, and 61 common pneumonia patients served as the controls. The liver functions of all the patients were measured. Results The rate of anomaly liver function in the common SARS patients group was 68.1%, which was higher than that in the common pneumonia patients group (24.6%), x2=27.7, P<0.01. The changes mainly existed in the mild to moderate elevation of alanine aminotransferase and aspartate aminotransferase. The severe SARS patients were older and the changing rate of liver function was as high as 95.7%. Conclusions The damage possibility of liver function in SARS patients is higher than that in common pneumonia patients. The damage is light and related to SARS itself. The damage of liver function in the severe SARS patients may have close relationship with age.