| α－双炔失碳酯对红细胞膜和钙调蛋白功能的影响 |
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| 引用本文： | 顾健,陈恩鸿,胥彬. α－双炔失碳酯对红细胞膜和钙调蛋白功能的影响[J]. 中国药理学通报, 1994, 0(3) |
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| 作者姓名： | 顾健 陈恩鸿 胥彬 |
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| 作者单位： | 中国科学院上海药物研究所 |
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| 摘 要： | 探讨α－双炔失碳酯对细胞膜功能的影响．结果表明，α－双炔失碳酯对红细胞溶血有很强的保护作用．１ｍｇ·Ｌ－１时保护率达７０％。该作用与α－双炔失碳酯对钙调蛋白功能的抑制有关。α－双炔失碳酯对钙调蛋白激活的Ｃａ２＋．Ｍｇ２＋－ＡＴＰ酶和钙调蛋白依赖性磷酸二酯酶的活力都有较明显的抑制作用，提示α－双炔失碳酯对钙信号系统的干扰可能与其抗肿瘤作用密切相关。
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| 关 键 词： | 双炔失碳酯，红细胞，钙调蛋白，Ca￣（2＋），Mg￣（2＋）－ATP酶，磷酸二酯酶 |
Effect of α-anordrin on erythrocyte membrane and calmodulin function |
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| GU Jian, CHENG En-Hong,XU Bin. Effect of α-anordrin on erythrocyte membrane and calmodulin function[J]. Chinese Pharmacological Bulletin, 1994, 0(3) |
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| Authors: | GU Jian CHENG En-Hong XU Bin |
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| Abstract: | The possible mechanisms of antitumor effect ofα-anordrin, a contraceptive, were studied. α-Anordrin had strong protective effect on erythrocyte, and the potective rate of erythrocyte aganist osmotic lysis at 1mg·L-1was 70%. Such effect was associated with the inhibition of calmodulin(CaM) function.α-Anordrin obviously inhibited the activity of CaM- activated Ca2+,Mg2+-ATPase and CaMdependent phosphodiesterase.It indicates that the inhibitory effect of α-anordrin on Ca2+ and CaM- dependent cellular signal pathway may be related to its antitumor activiry. |
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| Keywords: | anordrin erythrocyte calmodulin Ca￣(2+), Mg￣(2+)-ATPase phosphodiesterase |
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