Matrix metalloproteinase 9 in mucosally invasive gastric cancer |
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| Authors: | Akihito Torii Yasuhiro Kodera Masafumi Ito Yasuhiro Shimizu Takashi Hirai Kenzo Yasui Takeshi Morimoto Yoshitaka Yamamura Tomoyuki Kato Taro Hayakawa Noboru Fujimoto Tsuyoshi Kito |
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| Affiliation: | (1) Department of Gastroenterological Surgery, Aichi Cancer Center, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan, JP;(2) Department of Pathology, Nagoya University Hospital, Nagoya, Japan, JP;(3) Department of Biochemistry, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan, JP;(4) Biopharmaceutical Department, Fuji Chemical Industries, Takaoka, Japan, JP |
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| Abstract: | Background. Matrix metalloproteinase 9 (MMP-9) facilitates tumor invasion and metastasis via basement membrane degradation. Control of MMP-9 production by cancer-stromal cell interactions in these processes has been observed. Methods. We measured plasma MMP-9 concentrations, using a one-step sandwich enzyme immunoassay, and also immunohistochemically localized MMP-9 in patients with small gastric cancers limited to the mucosa. The cancers were classified as intraepithelial tumor (Tis) and T1 disease according to the tumor-node-metastasis (TNM) classification of the International Union Against Cancer. Results. Patients with T1 disease had a higher positivity rate for and mean value of MMP-9 than patients with Tis disease. In T1 tumors, MMP-9 expression determined immunohistochemically, was greater in cells in cancer stroma than in cells in noncancerous stroma, a situation found in only a few Tis tumors. Conclusions. These results suggest that MMP-9 is related to the initial step of gastric cancer invasion. Received for publication on Jun. 8, 1998; accepted on Oct. 20, 1998 |
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| Keywords: | : extracellular matrix stomach neoplasm metastasis tumor-stromal cell interaction |
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