Multislice T1‐prepared 2D single‐shot EPI: analysis of a clinical T1 mapping method unbiased by B0 or B1 inhomogeneity

Quantitative MR imaging is as sensitive in detecting lesions as qualitative imaging, but it is potentially more specific in differentiating disease. T₁ mapping in particular might help to assess acute ischemic stroke, multiple sclerosis, epilepsy and Alzheimer's disease better. Thus, a rapid and robust clinical technique is vital. In 1990, Ordidge and colleagues developed the multislice T₁ ‐prepared two‐dimensional (2D) single‐shot echo planar imaging technique. Subsequent studies demonstrated its clinical viability, but none performed an in‐depth analysis of the strengths and advantages of this T₁ mapping method. Herein, theoretical and experimental evidence shows that the technique accounts for 2D slice profile effects and is unbiased by B₀ or B₁ inhomogeneity. This is verified explicitly by varying the linear shims, the T₁ preparation flip angle and the excitation flip angle. Furthermore, it is shown that the repetition time (and hence scan time) can be reduced without a loss of T₁ accuracy. Copyright © 2016 John Wiley & Sons, Ltd.