丙型肝炎患者EPO、FA、VitB12水平和肝功能损伤的相关研究

目的:检测血清红细胞生成素(EPO)、叶酸(FA)、维生素B12(VitB12)水平在丙型肝炎病毒感染造成肝功能损伤过程损害中的作用。方法:采用放射免疫分析对62例丙型肝炎患者进行了血清EPO、FA、VitB12及肝功能相关的生化指标进行检测并以36名正常健康人作比较。结果:丙型肝炎患者血清EPO水平非常显著地高于正常人组(P<0.01)而FA和VitB12显著低于正常人组水平(P<0.01),EPO水平与肝功能损伤指标ALT、TBIL水平呈正相关,而FA和VitB12水平与ALT、TBIL水平成负相关。结论:检测丙型肝炎患者EPO、FA、VitB12水平在一定程度上反映了肝功能的损伤程度,具有临床实用价值。

Study on the Relationship Between Serum Erythropoietin (EPO), Folic Acid (FA),VitB12 Levels and Degree of Liver Function Impairment in Patients with Virus C Hepatitis

Objective To investigate the relationship between the levels of serum EPO, FA, VitB_ 12 and degree of liver injury in patients with hepatitis C virus infection. Methods Levels of serum EPO, FA, VitB_ 12 were detected with RIA and related liver function indicators (ALT total bilirubin) were also deter mined in 62 cases of virus C hepatitis and 36 controls. Results Serum levels of EPO in the patients were significantly higher than those in controls (P<0.01), while levels of FA and VitB_ 12 were significantly lower (P<0.01). The ALT and total bilirubin levels in the patients were positively correlated with those of EPO and negatively correlated with those of FA, VitB_ 12. Conclusion Changes of serum levels of EPO, FA and VitB_ 12 in patients with virus C hepatitis might reflect the degree of hepatic injury and determination of these changes was of clinical usefulness.