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益气活血降浊法防治慢性肾衰竭的实验研究
引用本文:于尔康,高继宁,李宜放,庞晓英.益气活血降浊法防治慢性肾衰竭的实验研究[J].中国中西医结合肾病杂志,2001,2(12):702-704.
作者姓名:于尔康  高继宁  李宜放  庞晓英
作者单位:1. 山西省中医药研究院肾病研究所,太原,030012
2. 山西中医学院,太原,030024
摘    要:目的:观察“肾毒灵”对慢性肾衰竭大鼠模型的保护作用,并探讨其疗效机制。方法:根据益气活血降浊法,制成“肾毒灵”胶囊,用0.75%腺嘌呤饲料喂养大鼠制成肾衰竭模型,灌胃观察“肾毒灵”胶囊的疗效。喂养50d后测血清中BUN、Scr、钙、磷、白蛋白和血色素的水平,并取肾组织做病理检查。结果:与对照组比较,“肾毒灵”胶囊可明显降低血清中BUN和Scr的含量,预防性拮抗钙磷失调;改善贫血和提高血浆蛋白的水平,同时减轻了肾组织的病理损害。结论:肾毒灵方具有促进氮质排泄,改善尿毒症合并症,减轻肾间质炎症,促进受损组织恢复的功能。

关 键 词:慢性肾衰竭  肾毒灵  病理  益气活血降浊法  中草药治疗
修稿时间:2000年7月28日

An Experimental Study of Prevention and Treatment on Chronic Renal Failure with Yi Qi Huo Xue Jiang Zhuo Fa
YU Erkang,GAO Jining,LI Yifang,et al.An Experimental Study of Prevention and Treatment on Chronic Renal Failure with Yi Qi Huo Xue Jiang Zhuo Fa[J].Chinese Journal of Integrated Traditional and Western Nephrology,2001,2(12):702-704.
Authors:YU Erkang  GAO Jining  LI Yifang  
Abstract:Objective:The capsule "Shen-du-ling"is made up of the drugs for supplementing qi,activating blood circulation and drainaging turbid materials from the body.Methods:the effect of which was observed on rat models of chronic renal failure induced by eating 0.75% adenine contained food.After the treatment of Shen-du-ling for 50 days,the level of blood urea nitrogen and serum creatinine was lower in the treated groups than those in the controls.Results:The drugs also increased the level of serum calcium and decreased the serum phosphorus in the treated groups.Conclusion:The light microscopy revealed that Shen-du-ling alleviated the pathological changes in the treated groups.
Keywords:Chronic renal failure  Shen Duling  Biochemistry  Pathology
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