A novel ultrasensitive surface plasmon resonance-based nanosensor for nitrite detection |
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| Authors: | Pandeng Miao Zhongdong Liu Jun Guo Ming Yuan Ruibo Zhong Liping Wang Feng Zhang |
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| Affiliation: | Grain College, Henan University of Technology, Zhengzhou 450001 P. R. China.; State Key Laboratory of Respiratory Disease, Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital, Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436 P. R. China.; School of Biomedical Engineering, Shanghai Jiaotong University, Shanghai 200241 P. R. China, |
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| Abstract: | Nitrite is a common food additive, however, its reduction product, nitrosamine, is a strong carcinogen, and hence the ultra-sensitive detection of nitrite is an effective means to prevent related cancers. In this study, different sized gold nanoparticles (AuNPs) were modified with P-aminothiophenol (ATP) and naphthylethylenediamine (NED). In the presence of nitrite, satellite-like AuNPs aggregates formed via the diazotization coupling reaction and the color of the system was changed by the functionalized AuNPs aggregates. The carcinogenic nitrite content could be detected by colorimetry according to the change in the system color. The linear concentration range of sodium nitrite was 0–1.0 μg mL−1 and the detection limit was determined to be 3.0 ng mL−1. Compared with the traditional method, this method has the advantages of high sensitivity, low detection limit, good selectivity and can significantly lower the naked-eye detection limit to 3.0 ng mL−1. In addition, this method is suitable for the determination of nitrite in various foods. We think this novel designed highly sensitive nitrate nanosensor holds great market potential.A satellite-like AuNP aggregate-based nitrite detection nanosensor was designed via diazotization coupling reaction and can significantly lower the naked-eye detection limit to 3.0 ng mL−1. This nanosensor has important applications in food detection and cancer prevention. |
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