Construction of a graphene/polypyrrole composite electrode as an electrochemically controlled release system |
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| Authors: | Mo Zhu Ying Hao Xun Ma Lin Feng Yuanxin Zhai Yaping Ding Guosheng Cheng |
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| Institution: | Department of Chemistry, Shanghai University, Shanghai 200444 P. R. China ; CAS Key Laboratory of Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Jiangsu 215123 P. R. China, |
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| Abstract: | A new class of stimuli responsive drug delivery systems is emerging to establish new paradigms for enhancing therapeutic efficacy. To date, most electro-responsive systems rely on noble metal electrodes that likely cause the limitations for implantation applications. Herein, a graphene/polypyrrole composite electrode (GN–PPy–FL) was fabricated based on two-dimensional (2D) graphene (GN) film and conductive and biocompatible polypyrrole (PPy) nanoparticles loaded with a negative drug model of fluorescein sodium (FL) via chemical oxidation polymerization. The conductive composite electrode was utilized as a drug carrier to realize the electrically controlled release of the FL. The release rate from conductive nanoparticles can be controlled by the applied voltages. The study provides a multi-stimuli responsive drug release system, demonstrating the potential applications of the controlled release of various drugs, peptides or proteins.A biocompatible conductive composite electrode GN–PPy–FL can realize controlled release of a drug model triggered by low voltages. |
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