One-pot synthesis of amides via the oxidative amidation of aldehydes and amines catalyzed by a copper-MOF |
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Authors: | Samira Jamalifard Javad Mokhtari Zohreh Mirjafary |
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Affiliation: | Department of Chemistry, Science and Research Branch, Islamic Azad University, P. O. box 14515/775, Tehran Iran, |
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Abstract: | An efficient method for the oxidative amidation of aldehydes with primary aromatic and aliphatic amines has been developed for the synthesis of a wide variety of amides using inexpensive Cu2(BDC)2DABCO (Cu-metal–organic framework [MOF]) as a recyclable heterogeneous catalyst, and N-chlorosuccinimide and aqueous tert-butyl hydroperoxide as oxidants in acetonitrile. This amidation reaction is operationally straightforward and provides secondary amides in good yields in most cases, utilizing inexpensive and readily available reagents under mild conditions.A method for oxidative amidation of aldehydes with primary amines was developed to synthesise a variety of amides using Cu2(BDC)2DABCO (Cu-MOF) as a recyclable heterogeneous catalyst, and N-chlorosuccinimide and aqueous tert-butyl hydroperoxide as oxidants in acetonitrile. |
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