Expeditious synthesis and preliminary antimicrobial activity of deflazacort and its precursors |
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| Authors: | Anna Esposito Eliana De Gregorio Maria De Fenza Daniele D'Alonzo Anil Satawani Annalisa Guaragna |
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| Affiliation: | Department of Chemical Sciences, University of Napoli Federico II, Via Cintia, 80126 Napoli Italy.; Department of Molecular Medicine and Medical Biotechnologies, Via S. Pansini, 5, 80131 Napoli Italy ; Symbiotec Pharmalab Pvt Ltd, Pithampur, Indore India |
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| Abstract: | The synthesis of deflazacort (DFZ) and a preliminary evaluation of its microbial activity against the human pathogens Acinetobacter baumannii and Staphylococcus aureus is herein reported. While DFZ is inactive, one of its synthetic precursors showed a strong antibacterial activity against both Gram-negative and -positive bacteria.Synthesis of deflazacort: unexpected antibacterial activity of its epoxide synthetic precursor. |
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